Biodegradable Mg Electrodes for Iontophoretic Transdermal Drug Delivery

Abstract Biodegradable metals have received limited attention for application in transdermal drug delivery, although metallic microneedles (MNs) and iontophoresis been thoroughly researched this purpose. Here, we present Mg as a salient candidate an MN electrode. Its properties enable the of voltage to enhance diffusion charged molecules, while hydrogen gas generated during corrosion prevents its electrodes. The electrode was fabricated using nanosecond laser, amount were measured with applied potential iontophoresis. Accordingly, appropriate window established based on combined effect enhanced by electric impediment from generation. dye permeation tests porcine skin demonstrated migration decreased at higher voltages due excess generation needle tips, both making molecules along surface harder. These results demonstrate optimal range electrodes delivery field bubble Graphical